In 2006, Nwodim, who is of Nigerian heritage, graduated from Eastern Technical High School in Essex, Maryland, near Baltimore. She received a biology degree from University of Southern California. Deciding to pursue a career in comedy, she began taking classes at the Upright Citizens Brigade Theatre (UCB) in Los Angeles. Until joining SNL, Nwodim was a regular cast member at UCB, where she also performed her one-woman show Great Black Women...and Then There's Me.
Nwodim was named one of the New Faces at the 2016 Just for Laughs festival. Also that year, she performed at the CBS Diversity Showcase. Supporting roles on television for Nwodim include Law & Order True Crime: The Menendez Murders (a three-episode arc in 2017), 2 Broke Girls, and Living Biblically. Impersonating Maya Angelou, Nwodim roasted various celebrities and companies in a 2017 Funny or Die sketch. Nwodim has made several guest appearances on podcasts such as Comedy Bang! Bang! and Spontaneanation.
Nwodim's addition to the cast of Saturday Night Live, a long-running NBC sketch-comedy show, as a featured player was announced on September 21, 2018. On September 8, 2020, Nwodim was promoted to a repertory player ahead of the forty-sixth season of Saturday Night Live.
- 2018-2020: Featured Player
- 2020-present: Repertory Player